Prof. Ueli Grossniklaus Department of Plant and Microbial Biology University of Zürich Zollikerstrasse 107 CH-8008 Zürich grossnik@botinst.uzh.ch phone: +41 (0)44 63 48240 fax: +41 (0)44 63 48204 Research Interests Keywords Education Previous Positions and Research Experience Fellowships and Awards List of Publications
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Research Interests

My main research interest lies in developmental genetics. After obtaining a PhD in Drosophila developmental biology I switched to working with plants when I set up an independent research group at Cold Spring Harbor Laboratory in 1994. I used a recently established enhancer detection method in Arabidopsis to study plant reproductive biology, both sexual and asexual (apomixis). Our research focuses on the elucidation of the genetic basis and the molecular mechanisms underlying three major areas: i) embryo sac development and double fertilization, ii) the engineering of apomixis, and iii) the maternal control of early embryogenesis, which is largely mediated through epigenetic effects. Both genomic imprinting and Polycomb group complex-mediated repression play an important role in regulating seed development.

Keywords

apomixis, cell specification, epigenetics, fertilization, gametophytes, plant reproduction

Education

Previous Positions and Research Experience

Fellowships and Awards

List of Publications

Mecchia MA, Rövekamp M, Giraldo-Fonseca A, Meier D, Gadient P, Vogler H, Limacher D, Bowman JL, Grossniklaus U. (2022) The single Marchantia polymorpha FERONIA homolog reveals an ancestral role in regulating cellular expansion and integrity. Development 149(19): dev200580.
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Hernandez-Lagana E, Mosca G, Sato EM, Pires N, Frey A, Giraldo-Fonseca A, Grossniklaus U, Hamant O, Godin C, Boudaoud A, Grimanelli D, Autran D, Baroux C. (2021). Organ geometry channels cell fate in the Arabidopsis ovule primordium. eLife 10: 66031.

Teano G, Concia L, Carron L, Wolff L, Adamusová K, Fojtová M, Bourge M, Kramdi A, Colot V, Grossniklaus U, Bowler C, Baroux C, Carbone A, Probst AV, Procházková Schrumpfová P, Fajkus J, Amiard S, Grob S, Bourbousse C, Barneche F. (2021). Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis. bioRxiv, 2020.2011.2028.402172. doi:10.1101/2020.11.28.402172
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Díaz M, Pecinková P, Nowicka A, Baroux C, Sakamoto T, Yuliani Gandha P, Jerábková H, Matsunaga H, Grossniklaus U, Pecinka A. (2019) The SMC5/6 Complex Subunit NSE4A Is Involved in DNA Damage Repair and Seed Development. The Plant Cell 31(7):1579-1597.
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Grob S, Grossniklaus U. (2019) Invasive DNA elements modify the nuclear architecture of their insertion site by KNOT-linked silencing in Arabidopsis thaliana. Genome Biol 20:120.

Kuon JE, Qi W, Schläpfer P, Hirsch-Hoffmann M, Rogalla von Bieberstein P, Patrignani A, Poveda L, Grob S, Keller M, Shimizu-Inatsugi R, Grossniklaus U, Vanderschuren H, Gruissem W. (2019) Haplotype-resolved genomes of geminivirus resistant and susceptible African cassava cultivars. BMC Biol 17.

Vogler H, Santos-Fernandez G, Mecchia MA, Grossniklaus U. (2019) To preserve or to destroy, that is the question: the role of the cell wall integrity pathway in pollen tube growth. Curr Opin Plant Biol. 52:131-139.
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Fabrice TN, Vogler H, Draeger C, Munglani G, Gupta S, Herger AG, Knox P, Grossniklaus U, Ringli C. (2018) LRX proteins play a crucial role in pollen grain and pollen tube cell wall development. Plant Physiol 176(3):1981-1992.
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Hedhly A, Vogler H, Eichenberger C, Grossniklaus U. (2018) Whole-mount clearing and staining of Arabidopsis flower organs and siliques. JoVE (134):e56441.
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Schmid MW*, Giraldo-Fonseca A*, Rövekamp M, Smetanin D, Bowman JL, Grossniklaus U. (2018) Extensive epigenetic reprogramming during the life cycle of Marchantia polymorpha. Genome Biology 19:9. (*These authors contributed equally to the publication).
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Bowman JL, Kohchi T, Yamato KT, Jenkins J, Shu S, Ishizaki K, Yamaoka S, Nishihama R, Nakamura Y, Berger F, Adam C, Aki SS, Althoff F, Araki T, Arteaga-Vazquez MA, Balasubrmanian S, Barry K, Bauer D, Boehm CR, Briginshaw L, Caballero-Perez J, Catarino B, Chen F, Chiyoda S, Chovatia M, Davies KM, Delmans M, Demura T, Dierschke T, Dolan L, Dorantes-Acosta AE, Eklund DM, Florent SN, Flores-Sandoval E, Fujiyama A, Fukuzawa H, Galik B, Grimanelli D, Grimwood J, Grossniklaus U, Hamada T, Haseloff J, Hetherington AJ, Higo A, Hirakawa Y, Hundley HN, Ikeda Y, Inoue K, Inoue SI, Ishida S, Jia Q, Kakita M, Kanazawa T, Kawai Y, Kawashima T, Kennedy M, Kinose K, Kinoshita T, Kohara Y, Koide E, Komatsu K, Kopischke S, Kubo M, Kyozuka J, Lagercrantz U, Lin SS, Lindquist E, Lipzen AM, Lu CW, De Luna E, Martienssen RA, Minamino N, Mizutani M, Mizutani M, Mochizuki N, Monte I, Mosher R, Nagasaki H, Nakagami H, Naramoto S, Nishitani K, Ohtani M, Okamoto T, Okumura M, Phillips J, Pollak B, Reinders A, Rövekamp M, Sano R, Sawa S, Schmid MW, Shirakawa M, Solano R, Spunde A, Suetsugu N, Sugano S, Sugiyama A, Sun R, Suzuki Y, Takenaka M, Takezawa D, Tomogane H, Tsuzuki M, Ueda T, Umeda M, Ward JM, Watanabe Y, Yazaki K, Yokoyama R, Yoshitake Y, Yotsui I, Zachgo S, Schmutz J. (2017) Insights into Land Plant Evolution Garnered from the Marchantia polymorpha Genome. Cell 171(2):287-304.
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Grob S, Grossniklaus U. (2017) Chromatin conformation capture-based analysis of nuclear architecture. Methods Mol Biol. 1456:15-32.

Hu C, Munglani G, Vogler H, Ndinyanka Fabrice T, Shamsudhin N, Wittel FK, Ringli C, Grossniklaus U, Herrmann HJ, Nelson BJ. (2017) Characterization of size-dependent mechanical properties of tip-growing cells using a lab-on-chip device. Lab Chip 17(1):82-90.
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Hu C, Vogler H, Aellen M, Shamsudhin N, Jang B, Burri JT, Läubli N, Grossniklaus U, Pané S, Nelson BJ. (2017) High precision, localized proton gradients and fluxes generated by a microelectrode device induce differential growth behaviors of pollen tubes. Lab Chip 17(4):671-680.
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Hu C, Zhang Q, Meyer T, Vogler H, Burri JT, Shamsudhin N, Grossniklaus U, Nelson BJ. (2017) In vivo tracking and measurement of pollen tube vesicle motion. 2017 IEEE International Conference on Robotics and Automation (ICRA) 2017 IEEE International Conference on Robotics and Automation (ICRA):3575-3580.
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Mecchia MA, Santos-Fernandez G, Duss NN, Somoza SC, Boisson-Dernier A, Gagliardini V, Martínez-Bernardini A, Fabrice TN, Ringli C, Muschietti JP, Grossniklaus U. (2017) RALF4/19 peptides interact with LRX proteins to control pollen tube growth in Arabidopsis. Science, 358(6370):1600-160.
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She W, Baroux C, Grossniklaus U. (2018) Cell-Type Specific Chromatin Analysis in Whole-Mount Plant Tissues by Immunostaining. Methods Mol Biol. 1675:443-454.
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Vogler H, Grossniklaus U, Hedhly A (2017) An Introduction to Male Germline Development. In Plant Germline Development (Schmidt A, ed). New York, NY: Springer New York, pp. 3-15.
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Vogler H, Shamsudhin N, Nelson BJ, Grossniklaus U (2017) Measuring cytomechanical forces on growing pollen tubes. In Pollen tip growth (Obermeyer G, Feijó J, eds). Cham: Springer International Publishing, pp. 65-85.
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Baroux C*, Pecinka A, Fuchs J, Kreth G, Schubert I, Grossniklaus U. (2016) Non-random chromosome arrangement in triploid endosperm nuclei. Chromosoma, in press (*, corresponding author)
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Burri JT, Hu C, Shamsudhin N, Wang X, Vogler H, Grossniklaus U, Nelson BJ. (2016) Dual-axis Cellular Force Microscope for mechanical characterization of living plant cells. 2016 IEEE International Conference on Automation Science and Engineering (CASE) 942-947.
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Hedhly A, Vogler H, Schmid MW, Pazmino D, Gagliardini V, Santelia D, Grossniklaus U. (2016) Starch Turnover and Metabolism during Flower and Early Embryo Development. Plant Physiol 172(4):2388-2402.
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Müller LM, Lindner H, Pires ND, Gagliardini V, Grossniklaus U. (2016) A subunit of the oligosaccharyltransferase complex is required for interspecific gametophyte recognition in Arabidopsis. Nat Commun. 7:10826.
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Pires ND, Bemer M, Müller LM, Baroux C, Spillane C, Grossniklaus U. (2016) Quantitative Genetics Identifies Cryptic Genetic Variation Involved in the Paternal Regulation of Seed Development. PLOS Genetics. doi:10.1371/journal.pgen.1005806.
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Rövekamp M, Bowman JL, Grossniklaus U. (2016) Marchantia MpRKD regulates the gametophyte-sporophyte transition by keeping egg cells quiescent in the absence of fertilization. Curr Biol. 26(13):1782-1789.
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Sailer C, Schmid B, Grossniklaus U. (2016) Apomixis Allows the Transgenerational Fixation of Phenotypes in Hybrid Plants. Curr Biol. 26(3):331-7.
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Shamsudhin N, Atakan HB, Laubli N, Vogler H, Hu C, Sebastian A, Grossniklaus U, Nelson BJ. (2016) Probing the micromechanics of the fastest growing plant cell — The pollen tube. 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
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Shamsudhin N, Laeubli N, Atakan HB, Vogler H, Hu C, Haeberle W, Sebastian A, Grossniklaus U, Nelson BJ. (2016) Massively parallelized pollen tube guidance and mechanical measurements on a lab-on-a-chip platform. PLoS One 11(12):e0168138.
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Vogler H, Martinez-Bernardini A, Grossniklaus U. (2016) Maybe she’s not the boss: Male-female crosstalk during sexual plant reproduction. Genome Biol 17(1):96.
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Wuest SE, Philipp MA, Guthörl D, Schmid B, Grossniklaus U. (2016) Correlative controls of seeds over maternal growth and senescence in Arabidopsis. Plant Physiol, in press.
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Baroux C, Grossniklaus U. (2015) Chapter Ten - The Maternal-to-Zygotic Transition in Flowering Plants: Evidence, Mechanisms, and Plasticity, In: Howard D. Lipshitz, Editor(s), Current Topics in Developmental Biology, Academic Press, Volume 113, Pages 351-371, ISSN 0070-2153, ISBN 9780124095236.
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Boisson-Dernier A, Franck CM, Lituiev DS, Grossniklaus U. (2015) Receptor-like cytoplasmic kinase MARIS functions downstream of CrRLK1L-dependent signaling during tip growth. Proc Natl Acad Sci U S A. 112(39):12211-6.
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Felekis D, Vogler H, Grossniklaus U, Nelson BJ (2015) Microrobotic tools for plant biology. In Micro- and Nanomanipulation Tools (Sun Y, Liu X, eds). Wiley-VCH Verlag GmbH & Co. KGaA, pp. 283-306.
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Felekis D, Vogler H, Mecja G, Muntwyler S, Nestorova A, Huang T, Sakar MS, Grossniklaus U, Nelson BJ. (2015) Real-time automated characterization of 3D morphology and mechanics of developing plant cells. The International Journal of Robotics Research 34(8):1136-1146.
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Kessler SA, Lindner H, Jones DS, Grossniklaus U. (2015) Functional analysis of related CrRLK1L receptor-like kinases in pollen tube reception. EMBO Rep. 16(1):107-15.
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Rubin BP, Brockes J, Galliot B, Grossniklaus U, Lobo D, Mainardi M, Mirouze M, Prochiantz A, Steger A. (2015) A dynamic architecture of life. F1000Res. 4:1288.
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Schmid MW*, Schmidt A*, Grossniklaus U. (2015) The female gametophyte: An emerging model for cell type-specific systems biology in plant development. Frontiers in Plant Science, 6:907. (* equal contribution)
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Schmid MW, Grob S, Grossniklaus U. (2015) HiCdat: a fast and easy-to-use Hi-C data analysis tool. BMC Bioinformatics 16:277.
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Schmid MW, Grossniklaus U. (2015) Rcount: simple and flexible RNA-Seq read counting. Bioinformatics 31:436-437.
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Schmidt A, Schmid MW, Grossniklaus U. (2015) Plant germline formation: molecular insights define common concepts and illustrate developmental flexibility in apomictic and sexual reproduction. Development 142:229-241.
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Singh AK, Bashir T, Sailer C, Gurumoorthy V, Ramakrishnan AM, Dhanapal S, Grossniklaus U, Baskar R. (2015) Parental age affects somatic mutation rates in the progeny of flowering plants. Plant Physiol. 168(1):247-57.
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Vogler H, Felekis D, Nelson BJ, Grossniklaus U. (2015) Measuring the mechanical properties of plant cell walls. Plants 4(2):167-182.
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Bashir T, Sailer C, Gerber F, Loganathan N, Bhoopalan H, Eichenberger C, Grossniklaus U, Baskar R. (2014) Hybridization alters spontaneous mutation rates in a parent-of-origin-dependent fashion in Arabidopsis. Plant Physiol. 165(1):424-37.
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Felekis D, Vogler H, Mecja G, Muntwyler S, Sakar MS, Grossniklaus U, Nelson BJ. (2014) High-throughput analysis of the morphology and mechanics of tip growing cells using a microrobotic platform. 2014 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2014) 3955-3960.
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Gossmann TI, Schmid MW, Grossniklaus U, Schmid KJ. (2014) Selection-driven evolution of sex-biased genes is consistent with sexual selection in Arabidopsis thaliana. Mol Biol Evol. 31(3):574-83.
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Grob, S, Schmid, MW, Grossniklaus, U. (2014). HiC Analysis in Arabidopsis Identifies the KNOT, a Structure with Similarities to the flamenco Locus of Drosophila. Molecular Cell, 55(5): 678-693.
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Grossniklaus U, Paro R. (2014) Transcriptional silencing by polycomb-group proteins. Cold Spring Harb Perspect Biol. 6(11):a019331.
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Lituiev DS, Grossniklaus U. (2014) Patterning of the angiosperm female gametophyte through the prism of theoretical paradigms. Biochem Soc Trans. 42(2):332-9.
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Ngo QA, Vogler H, Lituiev DS, Nestorova A, Grossniklaus U. (2014) A Calcium Dialog Mediated by the FERONIA Signal Transduction Pathway Controls Plant Sperm Delivery. Dev Cell 29:491-500.
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Pires ND, Grossniklaus U. (2014) Different yet similar: evolution of imprinting in flowering plants and mammals. F1000Prime Rep. 6:63.
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Sailer C, Schmid B, Stöcklin J, Grossniklaus U. (2014). Sexual Hieracium pilosella plants are better inter-specific, while apomictic plants are better intra-specific competitors. Perspectives in Plant Ecology, Evolution and Systematics, in press.
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Schmidt A, Schmid MW, Klostermeier UC, Qi W, Guthörl D, Sailer C, Waller M, Rosenstiel P, Grossniklaus U. (2014) Apomictic and Sexual Germline Development Differ with Respect to Cell Cycle, Transcriptional, Hormonal and Epigenetic Regulation. PLOS Genet. 10(7):e1004476.
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Wuest SE, Grossniklaus U. (2014) Laser-assisted microdissection applied to floral tissues. Methods Mol Biol. 1110:329-44.
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Baroux C, Autran D, Raissig MT, Grimanelli D, Grossniklaus U. (2013) Parental contributions to the transcriptome of early plant embryos. Curr Opin Genet Dev 23:72-74.
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Barrell P, Grossniklaus U. (2013) Examining female meiocytes of maize by confocal microscopy. Methods Mol Biol. 990:45-52.
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Boisson-Dernier A, Lituiev DS, Nestorova A, Franck CM, Thirugnanarajah S, Grossniklaus U. (2013) ANXUR Receptor-Like Kinases Coordinate Cell Wall Integrity with Growth at the Pollen Tube Tip Via NADPH Oxidases. PLoS Biol. 11(11):e1001719.
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Gossmann, TI, Schmid, MW, Grossniklaus, U, and Schmid, KJ. (2013) Selection-Driven Evolution of Sex-Biased Genes Is Consistent with Sexual Selection in Arabidopsis thaliana. Mol Biol Evol. 31(3): 574-583.
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Grob, S, Schmid, MW, Luedtke, NW, Wicker, T, and Grossniklaus, U. (2013) Characterization of chromosomal architecture in Arabidopsis by chromosome conformation capture. Genome Biol. 14:R129.
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Grossniklaus U, Kelly WG, Ferguson-Smith AC, Pembrey M, Lindquist S. (2013) Transgenerational epigenetic inheritance: how important is it? Nat Rev Genet. 14(3):228-35.
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Hirsch S, Baumberger R, Grossniklaus U. (2013) Epigenetic variation, inheritance and selection in plant populations. Cold Spring Habor Symposia on Quantitative Biology.
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Lindner M, Simonini S, Kooiker M, Gagliardini V, Somssich M, Hohenstatt M, Simon R, Grossniklaus U, Kater MM. (2013) TAF13 interacts with PRC2 members and is essential for Arabidopsis seed development. Dev Biol. 379(1):28-37.
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Lituiev DS, Krohn NG, Müller B, Jackson D, Hellriegel B, Dresselhaus T, Grossniklaus U. (2013) Theoretical and experimental evidence indicates that there is no detectable auxin gradient in the angiosperm female gametophyte. Development 140(22):4544-53.
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Ngo QA*, Albrecht H, Tsuchimatsu T, Grossniklaus U. (2013) The differentially regulated genes TvQR1 and TvPirin of the parasitic plant Triphysaria exhibit distinctive natural allelic diversity. BMC Plant Biol 13:28-38. (*Corresponding author)
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Raissig MT, Bemer M, Baroux C, Grossniklaus U. (2013) Genomic imprinting in the Arabidopsis embryo is partly regulated by PRC2. PLoS Genet. 9(12):e1003862.
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Raissig MT, Gagliardini V, Jaenisch J, Grossniklaus U, Baroux C. (2013) Efficient and Rapid Isolation of Early-stage Embryos from Arabidopsis thaliana Seeds. J. Vis. Exp. (76), e50371.
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Schmidt A, Wöhrmann HJ, Raissig MT, Arand J, Gheyselinck J, Gagliardini V, Heichinger C, Walter J, Grossniklaus U. (2013) The Polycomb group protein MEDEA and the DNA methyltransferase MET1 interact to repress autonomous endosperm development in Arabidopsis. Plant J. 73(5):776-87.
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Sedeek KEM, Qi W, Schauer MA, Gupta AK, Poveda L, Xu S, Liu Z-J, Grossniklaus U, Schiestl FP, Schlüter PM. (2013) Transcriptome and proteome data reveal candidate genes for pollinator attraction in sexually deceptive orchids. PLoS ONE 8(5): e64621.
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Vogler H, Draeger C, Weber A, Felekis D, Eichenberger C, Routier-Kierzkowska AL, Boisson-Dernier A, Ringli C, Nelson BJ, Smith RS, Grossniklaus U. (2013) The pollen tube: a soft shell with a hard core. Plant J 73:617-627.
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Wuest SE, Schmid MW, Grossniklaus U. (2013) Cell-specific expression profiling of rare cell types as exemplified by its impact on our understanding of female gametophyte development. Curr Opin Plant Biol., 16:41-9.
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Bemer M, Grossniklaus U. (2012) Dynamic regulation of Polycomb group activity during plant development. Curr Opin Plant Biol. 15(5):523-9.
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Iwano M*, Ngo QA*, Entani T, Shiba H, Nagai T, Miyawaki A, Isogai A, Grossniklaus U, Takayama S. (2012) Cytoplasmic Ca2+ changes dynamically during the interaction of the pollen tube with synergid cells. Development 139:4202-4209. (*Equal Contribution)
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Jones AM, Aebersold R, Ahrens CH, Apweiler R, Baerenfaller K, Baker M, Bendixen E, Briggs S, Brownridge P, Brunner E, Daube M, Deutsch EW, Grossniklaus U, Heazlewood J, Hengartner MO, Hermjakob H, Jovanovic M, Lawless C, Lochnit G, Martens L, Ravnsborg C, Schrimpf SP, Shim YH, Subasic D, Tholey A, Wijk Kv, Mering Cv, Weiss M, Zheng X. (2012) The HUPO initiative on Model Organism Proteomes, iMOP. Proteomics. 12(3):340-5.
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Kritsas K, Wuest SE, Hupalo D, Kern AD, Wicker T, Grossniklaus U. (2012) Computational analysis and characterization of UCE-like elements (ULEs) in plant genomes. Genome Res. 22(12):2455–2466.
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Leshem Y, Johnson C, Wuest SE, Song X, Ngo QA, Grossniklaus U, Sundaresan V. (2012) Molecular characterization of the glauce mutant: a central cell-specific function is required for double fertilization in Arabidopsis. Plant Cell 24:3264-3277.
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Lindner H, Müller LM, Boisson-Dernier A, Grossniklaus U. (2012) CrRLK1L receptor-like kinases: not just another brick in the wall. Curr Opin Plant Biol. epub.
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Lindner H, Raissig MT, Sailer C, Shimosato-Asano H, Bruggmann R, Grossniklaus U. (2012) SNP-Ratio Mapping (SRM): Identifying Lethal Alleles and Mutations in Complex Genetic Backgrounds by Next-Generation Sequencing. Genetics 191(4):1381-1386.
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Marshall A, Aalen RB, Audenaert D, Beeckman T, Broadley MR, Butenko MA, Caño-Delgado AI, de Vries S, Dresselhaus T, Felix G, Graham NS, Foulkes J, Granier C, Greb T, Grossniklaus U, Hammond JP, Heidstra R, Hodgman C, Hothorn M, Inzé D, Ostergaard L, Russinova E, Simon R, Skirycz A, Stahl Y, Zipfel C, De Smet I. (2012) Tackling drought stress: receptor-like kinases present new approaches. Plant Cell. 24(6):2262-78.
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Mayank P, Grossman J, Wuest S, Boisson-Dernier A, Roschitzki B, Nanni P, Nühse T, Grossniklaus U. (2012) Characterization of the phosphoproteome of mature Arabidopsis pollen. Plant J. 72(1):89-101.
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Ngo QA*, Baroux C, Guthörl D, Mozerov P, Collinge MA, Sundaresan V, Grossniklaus U. (2012) The Armadillo repeat gene ZAK IXIK promotes Arabidopsis early embryo and endosperm development through a distinctive gametophytic maternal effect. Plant Cell 24:4026-4043. (*Corresponding author)
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Petricka JJ, Schauer MA, Megraw M, Breakfield NW, Thompson JW, Georgiev S, Soderblom EJ, Ohler U, Moseley MA, Grossniklaus U, Benfey PN. (2012) The protein expression landscape of the Arabidopsis root. Proc Natl Acad Sci U S A. 109(18):6811-8.
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Pires ND, Grossniklaus U. (2012) How to fine-tune an epigenetic switch. Dev Cell. 23(3):453-4.
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Schmid MW, Schmidt A, Klostermeier UC, Barann M, Rosenstiel P, Grossniklaus U. (2012). A powerful method for transcriptional profiling of specific cell types in eukaryotes: laser-assisted microdissection and RNA sequencing. PLoS ONE 7(1):e29685.
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Schmidt A, Schmid MW, Grossniklaus U. (2012). Analysis of plant germline development by high-throughput RNA profiling: technical advances and new insights. Plant J. 70(1):18-29.
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Sprunck S, Rademacher S, Vogler F, Gheyselinck J, Grossniklaus U, Dresselhaus T. (2012) Egg cell-secreted EC1 triggers sperm cell activation during double fertilization. Science. 338(6110):1093-7.
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Xu S, Schlüter PM, Grossniklaus U, Schiestl FP. (2012) The genetic basis of pollinator adaptation in a sexually deceptive orchid. PLoS Genet. 8(8):e1002889.
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You W, Tyczewska A, Spencer M, Daxinger L, Schmid MW, Grossniklaus U, Simon S, Meyers BC, Matzke AJM, Matzke M. (2012). Atypical DNA methylation of genes encoding cysteine-rich peptides in Arabidopsis thaliana. BMC Plant Biol. 12:51.
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Züst T, Heichinger C, Grossniklaus U, Harrington R, Kliebenstein DJ, Turnbull LA. (2012) Natural enemies drive geographic variation in plant defenses. Science 338:116-119.
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Autran D*, Baroux C*, Raissig MT, Lenormand T, Wittig M, Grob S, Steimer A, Barann M, Klostermeier UC, LeblancO , Vielle-Calzada J-P, Rosenstiel P, Grimanelli D, Grossniklaus U. (2011) Maternal epigenetic pathways control parental contributions to Arabidopsis early embryogenesis, Cell, 145(5):707-19. *Equal Contribution
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Baroux C, Raissig MT, Grossniklaus U. (2011) Epigenetic regulation and reprogramming during gamete formation in plants. Curr Opin Genet Dev. 21(2):124-33.
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Boisson-Dernier A, Kessler SA, Grossniklaus U. (2011) The walls have ears: the role of plant CrRLK1Ls in sensing and transducing extracellular signals. J Exp Bot 62(5):1581-91.
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Brukhin VB, Jaciubek M, Bolaños Carpio A, Kuzmina V, Grossniklaus U. (2011) Female gametophytic mutants of Arabidopsis thaliana identified in a gene trap insertional mutagenesis screen. Int J Dev Biol. 55(1):73-84.
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Dumbliauskas E, Lechner E, Jaciubek M, Berr A, Pazhouhandeh M, Alioua M, Cognat V, Brukhin V, Koncz C, Grossniklaus U, Molinier J, Genschik P. (2011) The Arabidopsis CUL4-DDB1 complex interacts with MSI1 and is required to maintain MEDEA parental imprinting. EMBO J. 30(4):731-43
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Felekis D, Muntwyler S, Vogler H, Beyeler F, Grossniklaus U, Nelson BJ. (2011) Quantifying growth mechanics of living, growing plant cells in situ using microrobotics. Micro Nano Lett 6:311-316.
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Grossniklaus U. (2011) Plant germline development: a tale of cross-talk, signaling, and cellular interactions. Sex Plant Reprod. 24(2):91-5.
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Kessler SA, Grossniklaus U. (2011) She's the boss: signaling in pollen tube reception. Curr Opin Plant Biol. 14(5):622-7.
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Kirioukhova O, Johnston AJ, Kleen D, Kägi C, Baskar R, Moore JM, Bäumlein H, Gross-Hardt R, Grossniklaus U. (2011) Female gametophytic cell specification and seed development require the function of the putative Arabidopsis INCENP ortholog WYRD. Development. 138(16):3409-20.
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Koszegi D, Johnston AJ, Rutten T, Czihal A, Altschmied L, Kumlehn J, Wüst SE, Kirioukhova O, Gheyselinck J, Grossniklaus U, Bäumlein H. (2011) Members of the RKD transcription factor family induce an egg cell-like gene expression program. Plant J. 2011 67(2):280-91.
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McKeown PC, Laouielle-Duprat S, Prins P, Wolff P, Schmid MW, Donoghue MTA, Fort A, Duszynska D, Comte A, Lao NT, Wennblom TJ, Smant G, Köhler C, Grossniklaus U, Spillane C. (2011). Identification of imprinted genes subject to parent-of-origin specific expression in Arabidopsis thaliana seeds. BMC Plant Biol. 11:113.
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Paszkowski J, Grossniklaus U. (2011) Selected aspects of transgenerational epigenetic inheritance and resetting in plants. Curr Opin Plant Biol. 14(2):195-203.
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Raissig MT, Baroux C, Grossniklaus U. (2011) Regulation and Flexibility of Genomic Imprinting during Seed Development. Plant Cell 23(1):16-26.
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Schlüter PM, Xu S, Gagliardini V, Whittle EJ, Shanklin J, Grossniklaus U, Schiestl FP. (2011) Stearoyl-acyl carrier protein desaturases are associated with floral isolation in sexually deceptive orchids. Proc. Natl. Acad. Sci. USA 108:5696-5701.
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Schmidt A, Wüst SE, Vijverberg K, Baroux C, Kleen D, Grossniklaus, U. (2011) Transcripome analysis of the Arabidopsis megaspore mother cell uncovers the Importance of RNA helicases for plant germline development. PLoS Biol 9(9): e1001155.
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Aquea F, Johnston AJ, Cañon P, Grossniklaus U, Arce-Johnson P. (2010) TRAUCO, a Trithorax-group gene homologue, is required for early embryogenesis in Arabidopsis thaliana. J Exp Bot. 61(4):1215-24.
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Fakheran S, Paul-Victor C, Heichinger C, Schmid B, Grossniklaus U, Turnbull LA (2010). Adaptation and extinction in experimentally fragmented landscapes. PNAS 107(44):19120-5
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Johnston AJ, Kirioukhova O, Barrell PJ, Rutten T, Moore JM, Baskar R, Grossniklaus U, Gruissem W. (2010) Dosage-sensitive function of retinoblastoma related and convergent epigenetic control are required during the Arabidopsis life cycle. PLoS Genet. 6(6).
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Keinath NF, Kierszniowska S, Lorek J, Bourdais G, Kessler SA, Shimosato-Asano H, Grossniklaus U, Schulze WX, Robatzek S, Panstruga R. (2010) PAMP (pathogen-associated molecular pattern)-induced changes in plasma membrane compartmentalization reveal novel components of plant immunity. J Biol Chem 10:285(50)39140-9.
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Kessler SA, Shimosato-Asano H, Keinath NF, Wuest SE, Ingram G, Panstruga R, Grossniklaus U. (2010) Conserved molecular components for pollen tube reception and fungal invasion. Science 330(6006):968-71.
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Matias-Hernandez L, Battaglia R, Galbiati F, Rubes M, Eichenberger C, Grossniklaus U, Kater MM, Colombo L. (2010) VERDANDI is a direct target of the MADS domain ovule identity complex and affects embryo sac differentiation in Arabidopsis. Plant Cell. 22(6):1702-15.
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Müller B, Grossniklaus U. (2010) Model organisms - A historical perspective. J Proteomics 73(11):2054-63.
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Pien S, Grossniklaus U. (2010) Chromatin immunoprecipitation protocol for histone modifications and protein-DNA binding analyses in Arabidopsis. Methods Mol Biol. 631:209-20.
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Pillot M, Baroux C, Vazquez MA, Autran D, Leblanc O, Vielle-Calzada JP, Grossniklaus U, Grimanelli D. (2010) Embryo and endosperm inherit distinct chromatin and transcriptional states from the female gametes in Arabidopsis. Plant Cell. 22(2):307-20.
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Wuest SE, Vijverberg K, Schmidt A, Weiss M, Gheyselinck J, Lohr M, Wellmer F, Rahnenführer J, von Mering C, Grossniklaus U. (2010) Arabidopsis female gametophyte gene expression map reveals similarities between plant and animal gametes. Curr Biol. 20(6):506-12.
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Boisson-Dernier A, Roy S, Kritsas K, Grobei MA, Jaciubek M, Schroeder JI, Grossniklaus U. (2009) Disruption of the pollen-expressed FERONIA homologs ANXUR1 and ANXUR2 triggers pollen tube discharge. Development. 136(19):3279-88.
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Grobei MA, Qeli E, Brunner E, Rehrauer H, Zhang R, Roschitzki B, Basler K, Ahrens CH, Grossniklaus U. (2009) Deterministic protein inference for shotgun proteomics data provides new insights into Arabidopsis pollen development and function. Genome Res. 19(10):1786-800.
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Grossniklaus U. (2009) Evolution of Imprinting. Annu Rev Cell Dev Biol.
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Grossniklaus U. (2009) Plant science. Paternal patterning cue. Science. 323(5920):1439-40.
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Schauer SE, Schlüter PM, Baskar R, Gheyselinck J, Bolaños A, Curtis MD, Grossniklaus U. (2009) Intronic regulatory elements determine the divergent expression patterns of AGAMOUS-LIKE6 subfamily members in Arabidopsis. Plant J. 59:987-1000.
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Baerenfaller K, Grossmann J, Grobei MA, Hull R, Hirsch-Hoffmann M, Yalovsky S, Zimmermann P, Grossniklaus U, Gruissem W, Baginsky S. (2008) Genome-scale proteomics reveals Arabidopsis thaliana gene models and proteome dynamics. Science 320(5878):938-41
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Baroux C, Autran D, Gillmor CS, Grimanelli D, Grossniklaus U. (2008) The maternal to zygotic transition in animals and plants. Cold Spring Harb Symp Quant Biol. 73:89-100.
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Bemer M, Wolters-Arts M, Grossniklaus U, Angenent GC. (2008) The MADS domain protein DIANA acts together with AGAMOUS-LIKE80 to specify the central cell in Arabidopsis ovules. Plant Cell. 20(8):2088-101
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Curtis MD, Grossniklaus U. (2008) Molecular control of autonomous embryo and endosperm development. Sex Plant Reprod. 21:79–88.
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Guggisberg A, Baroux C, Grossniklaus U, Conti E. (2008) Genomic origin and organization of the allopolyploid Primula egaliksensis investigated by in situ hybridization. Ann Bot (Lond) 101:919-927.
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Johnston AJ, Matveeva E, Kirioukhova O, Grossniklaus U, Gruissem W. (2008) A dynamic reciprocal RBR-PRC2 regulatory circuit controls Arabidopsis gametophyte development. Curr Biol. 18(21):1680-6
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Moll C, von Lyncker L, Zimmermann S, Kägi C, Baumann N, Twell D, Grossniklaus U, Gross-Hardt R. (2008) CLO/GFA1 and ATO are novel regulators of gametic cell fate in plants. Plant J. 56(6):913-21
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Pien S, Fleury D, Mylne JS, Crevillen P, Inzé D, Avramova Z, Dean C, Grossniklaus U. (2008) ARABIDOPSIS TRITHORAX1 dynamically regulates FLOWERING LOCUS C activation via histone 3 lysine 4 trimethylation. Plant Cell. 20(3):580-8
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Haun WJ, Laoueille-Duprat S, O'connell MJ, Spillane C, Grossniklaus U, Phillips AR, Kaeppler SM, Springer NM. (2007) Genomic imprinting, methylation and molecular evolution of maize Enhancer of zeste (Mez) homologs. Plant J. 49(2):325-37.
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Gross-Hardt R, Kägi C, Baumann N, Moore JM, Baskar R, Gagliano WB, Jürgens G, Grossniklaus U. (2007) LACHESIS Restricts Gametic Cell Fate in the Female Gametophyte of Arabidopsis. PLoS Biol. 5(3):e47.
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Pien S, Grossniklaus U. (2007) Polycomb group and trithorax group proteins in Arabidopsis. Biochim Biophys Acta. 1769(5-6):375-382
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Baroux C, Pecinka A, Fuchs J, Schubert I, Grossniklaus U. (2007) The triploid endosperm genome of Arabidopsis adopts a peculiar, parental-dosage-dependent chromatin organization. Plant Cell 19(6):1782-94.
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Baroux C, Pien S, Grossniklaus U. (2007) Chromatin modification and remodeling during early seed development. Curr Opin Genet Dev 17:1-7.
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Chekanova JA, Gregory BD, Reverdatto SV, Chen H, Kumar R, Hooker T, Yazaki J, Li P, Skiba N, Peng Q, Alonso J, Brukhin V, Grossniklaus U, Ecker JR, Belostotsky DA. (2007) Genome-wide high-resolution mapping of exosome substrates reveals hidden features in the Arabidopsis transcriptome. Cell. 131(7):1340-53.
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Chen YH, Li HJ, Shi DQ, Yuan L, Liu J, Sreenivasan R, Baskar R, Grossniklaus U, Yang WC. (2007) The central cell plays a critical role in pollen tube guidance in Arabidopsis. Plant Cell. 19(11):3563-77.
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Curtis MD, Grossniklaus U. (2007) Plant Genetics and Development. In: Encyclopedia of Life Sciences. John Wiley & Sons, Ltd: Chichester
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Escobar-Restrepo JM, Huck N, Kessler S, Gagliardini V, Gheyselinck J, Yang WC, Grossniklaus U. (2007) The FERONIA receptor-like kinase mediates male-female interactions during pollen tube reception. Science. 317:606-7.
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Johnston AJ, Meier P, Gheyselinck J, Wuest SE, Federer M, Schlagenhauf E, Becker JD, Grossniklaus U. (2007) Genetic subtraction profiling identifies genes essential for Arabidopsis reproduction and reveals interaction between the female gametophyte and the maternal sporophyte. Genome Biol. 8(10):R204.
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Langer M, Sniderhan LF, Grossniklaus U, Ray A. (2007) Transposon Excision from an Atypical Site: A Mechanism of Evolution of Novel Transposable Elements. PLoS ONE 2(10):e965.
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Ngo QA, Moore JM, Baskar R, Grossniklaus U, Sundaresan V. (2007) Arabidopsis GLAUCE promotes fertilization-independent endosperm development and expression of paternally inherited alleles. Development. 134:4107-4117.
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Spillane C, Schmid KJ, Laoueillé-Duprat S, Pien S, Escobar-Restrepo JM, Baroux C, Gagliardini V, Page DR, Wolfe KH, Grossniklaus U. (2007) Positive darwinian selection at the imprinted MEDEA locus in plants. Nature 448:349-52.
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Makarevich G, Leroy O, Akinci U, Schubert D, Clarenz O, Goodrich J, Grossniklaus U, Kohler C. (2006) Different Polycomb group complexes regulate common target genes in Arabidopsis. EMBO Rep. 7(9):947-52.
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Zhang W, Sun Y, Timofejeva L, Chen C, Grossniklaus U, Ma H. (2006) Regulation of Arabidopsis tapetum development and function by DYSFUNCTIONAL TAPETUM1 (DYT1) encoding a putative bHLH transcription factor. Development. 133(16):3085-95.
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da Costa-Nunes JA, Bhatt AM, O'Shea S, West CE, Bray CM, Grossniklaus U, Dickinson HG. (2006) Characterization of the three Arabidopsis thaliana RAD21 cohesins reveals differential responses to ionizing radiation. J Exp Bot. 57(4):971-83.
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Brand L, Horler M, Nuesch E, Vassalli S, Barrell P, Yang W, Jefferson RA, Grossniklaus U, Curtis MD. (2006) A versatile and reliable two-component system for tissue-specific gene induction in Arabidopsis. Plant Physiol. 141(4):1194-204.
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de Folter S, Shchennikova AV, Franken J, Busscher M, Baskar R, Grossniklaus U, Angenent GC, Immink RG. (2006) A Bsister MADS-box gene involved in ovule and seed development in petunia and Arabidopsis. Plant J. 47(6):934-46.
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Baroux C, Gagliardini V, Page DR, Grossniklaus U. (2006) Dynamic regulatory interactions of Polycomb group genes: MEDEA autoregulation is required for imprinted gene expression in Arabidopsis. Genes Dev. 20(9):1081-6.
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Schöb H, Grossniklaus U. (2006) The first high-resolution DNA "methylome". Cell. 126(6):1025-8.
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Köhler C, Grossniklaus U. (2005) Seed development and genomic imprinting in plants. Prog Mol Subcell Biol. 38:237-62

Day RC, Grossniklaus U, Macknight RC. (2005) Be more specific! Laser-assisted microdissection of plant cells. Trends Plant Sci. 10(8):397-406.
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Geisler M, Blakeslee JJ, Bouchard R, Lee OR, Vincenzetti V, Bandyopadhyay A, Titapiwatanakun B, Peer WA, Bailly A, Richards EL, Ejendal KF, Smith AP, Baroux C, Grossniklaus U, Muller A, Hrycyna CA, Dudler R, Murphy AS, Martinoia E. (2005) Cellular efflux of auxin catalyzed by the Arabidopsis MDR/PGP transporter AtPGP1. Plant J. 44(2):179-94.
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Grossniklaus U. (2005) Genomic imprinting in plants: a predominantly maternal affair. In (P. Meyer, ed), Blackwell, Sheffield

Thomann A, Brukhin V, Dieterle M, Gheyeselinck J, Vantard M, Grossniklaus U, Genschik P. (2005) Arabidopsis CUL3A and CUL3B genes are essential for normal embryogenesis. Plant J. 43(3):437-48.
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Huanca-Mamani W, Garcia-Aguilar M, Leon-Martinez G, Grossniklaus U, Vielle-Calzada JP. (2005) CHR11, a chromatin-remodeling factor essential for nuclear proliferation during female gametogenesis in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 102(47):17231-6
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Yang W, Jefferson RA, Huttner E, Moore JM, Gagliano WB, Grossniklaus U. (2005) An egg apparatus-specific enhancer of Arabidopsis, identified by enhancer detection. Plant Physiol. 139(3):1421-32
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Brukhin V, Curtis MD, Grossniklaus U. (2005) The angiosperm female gametophyte: no longer the forgotten generation. Current Science, 89:1844-1852.
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Curtis MD, Grossniklaus U. (2005) Thale Cress (Arabidopsis thaliana) genome. In: Meyers RA (ed) Encyclopedia of Molecular Cell Biology and Molecular Medicine (2nd ed), Wiley-VCH Publisher, Weinheim, Germany, pp 245-282.

Barrell PJ, Grossniklaus U. (2005) Confocal microscopy of whole ovules for analysis of reproductive development: the elongate1 mutant affects meiosis II. Plant J. 43(2):309-20
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Köhler C, Page DR, Gagliardini V, Grossniklaus U. (2005) The Arabidopsis thaliana MEDEA Polycomb group protein controls expression of PHERES1 by parental imprinting. Nat Genet. 37:28-30.
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Lalanne E, Michaelidis C, Moore JM, Gagliano WB, Johnson A, Pater R, Howden R, Vielle-Calzada J-P, Grossniklaus U, Twell D. (2004) Analysis of transposon insertion mutants highlights the diversity of mechanisms underlying male programic development in Arabidopsis. Genetics 167:1975-86.
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Page DR, Köhler C, da Costa-Nunes JA, Baroux C, Moore JM, Grossniklaus U. (2004) Intrachromosomal excision of a hybrid Ds element induces large genomic deletions in Arabidopsis. Proc. Natl. Acad. Sci. USA 101(9):2969-74.
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Spillane C, Curtis MD, Grossniklaus U. (2004) Apomixis technology development - virgin births in farmers' fields? Nat Biotechnol 22:687-691.
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Steimer A, Schöb H, Grossniklaus U. (2004) Epigenetic control of plant development: new layers of complexity. Curr Opin Plant Biol. 7(1):11-19.
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Curtis MD, Brand L, Yang W, Nüesch E, Moore JM, Jefferson R, Grossniklaus U. (2004) Apomixis Technology Development: Transgene Containment and Fixation of Heterosis. , pp. 167-173.

Lalanne E, Honys D, Johnson A, Borner GH, Lilley KS, Dupree P, Grossniklaus U, Twell D. (2004) SETH1 and SETH2, two components of the glycosylphosphatidylinositol anchor biosynthetic pathway, are required for pollen germination and tube growth in Arabidopsis. Plant Cell. 16(1):229-40.
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Sieber P, Gheyselinck J, Gross-Hardt R, Laux T, Grossniklaus U, Schneitz K. (2004) Pattern formation during early ovule development in Arabidopsis thaliana. Devl. Biol. 273:321-34.
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Bernasconi G, Ashman T-L, Birkhead TR, Bishop JDD, Grossniklaus U, Kubli E, Marshall DL, Schmid B, Skogsmyr BI, Snook RR, Taylor D, Till-Bottraud I, Ward PI, Zeh DW, Hellriegel B (2004) Evolutionary ecology of the pre-zygotic stage. Science 303(5660):971-5.
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Guitton A-E, Page DR, Chambrier P, Lionnet C, Faure JE, Grossniklaus U, Berger F. (2004) Identification of new members Fertilisation Independent Seed Polycomb Group pathway involved in the control of seed development in Development 131:2971-81.
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Hennig L, Gruissem W, Grossniklaus U, Köhler C. (2004) Transcriptional programs of early reproductive stages in Arabidopsis. Plant Phys. 135:1765-1775.
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Baroux C, Fransz P, Grossniklaus U. (2004) Nuclear fusions contribute to polyploidization of the gigantic nuclei in the chalazal endosperm of Arabidopsis. Planta 220(1):38-46.
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Collinge MA, Spillane C, Köhler C, Gheyselinck J, Grossniklaus U. (2004) Genetic interaction of an origin recognition complex subunit and the Polycomb group gene MEDEA during seed development. Plant Cell. 16(4):1035-46.
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Spillane C, Baroux C, Escobar-Restrepo J-M, Page DR, Laoueille S, Grossniklaus U. (2004) Transposons and tandem repeats are not involved in the control of genomic imprinting at the MEDEA locus in Arabidopsis. 69:465-75
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Alvarez-Venegas R, Pien S, Sadder M, Witmer X, Grossniklaus U, Avramova Z. (2003) ATX-1, an Arabidopsis homolog of trithorax, activates flower homeotic genes. Curr Biol. 13:627-37.
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Huck N, Moore JM, Federer M, Grossniklaus U. (2003) The female gametophytic control of pollen tube reception is disrupted in the Arabidopsis mutant feronia. Development 130:2149-59.
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Köhler C, Hennig L, Spillane C, Pien S, Gruissem W, Grossniklaus U. (2003) The Polycomb-group protein MEDEA regulates seed development by controlling expression of the MADS-box gene PHERES1. Genes & Dev. 17:1540-53.
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Oh S-A, Park S-K, Jang I, Moore JM, Grossniklaus U, Twell D. (2003) halfman1, an Arabidopsis male gametophytic mutant associated with a 150 kb chromosomal deletion at the site of transposon insertion. Sex. Plant Reprod. 16:99-102.

Reyes JC, Grossniklaus U. (2003) Diverse functions of Polycomb group proteins during plant development. Sem. Cell Devl. Biol. 14:77-84.
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da Costa-Nunes JA, Grossniklaus U. (2003). Unveiling the gene-expression profile of pollen. Genome Biology 5:205.1-205.3.
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Curtis MD, Grossniklaus U. (2003) A gateway cloning vector set for high-throughput functional analysis of genes in planta. Plant Physiol. 133:462-9.
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Grossniklaus U, Moore JM, Brukhin V, Gheyselinck J, Baskar R, Vielle-Calzada J-P, Baroux C, Page DR, Spillane C. (2003) Engineering of apomixis in crop plants: what can we learn from sexual model systems. In: Plant Biotechnology 2002 and Beyond (Vasil I. ed), Kluver Academic Pulishers, Dordrecht, pp. 309-314.

Koltunow AM, Grossniklaus U. (2003) Apomixis: a developmental perspective. Ann. Rev. Plant Devl. 54:547-74.
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Pruitt RE, Bowman JL, Grossniklaus U. (2003) Plant genetics: a decade of integration. Nature Genetics 33 Suppl: 294-304.
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Köhler C, Hennig L, Bouveret R, Gheyselinck J, Grossniklaus U, Gruissem W. (2003) Arabidopsis MSI1 is a component of the MEA/FIE Polycomb group complex and required for seed development. EMBO J. 22:4804-14.
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Chen C, Marcus A, Li W, Hu Y, Vielle-Calzada J-P, Grossniklaus U, Cyr R, Ma H. (2002) The Arabidopsis KIT1 gene is required for spindle morphogenesis in male meiosis. Development 129:2401-2409.
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Grossniklaus U, Keller B, Linder HP. (2002) Wissenschaftliche Forschung im Botanischen Garten. Züriberg 20:7.

Köhler C, Grossniklaus U. (2002) Epigenetic inheritance of expression states in plant development: the role of Polycomb group proteins. Curr. Opin. Cell Biol. 14:773-779.
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Spillane C, Vielle-Calzada J-P, Grossniklaus U. (2002) Parent-of-origin effects and seed development: Genetics and epigenetics. In The Handbook of Transgenic Food Plants (Hui YH, Khachatourians GG, McHughen A, Nip WK, Scorza R. eds). Marcel Dekker Inc., New York, USA. 109-136.

Baroux C, Spillane C, Grossniklaus U. (2002) Evolutionary origins of the endosperm in flowering plants. Genome Biol. 3:1026.1-1026.5.
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Baroux C, Spillane C, Grossniklaus U. (2002) Genomic imprinting during seed development. In Advances in Genetics: Homology Effects (Dunlap JC, Wu C-T. eds). Academic Press, San Diego, USA. pp. 165-214.
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Golden TA, Schauer SE, Lang JD, Pien S, Mushegian AR, Grossniklaus U, Meinke DW, Ray A. (2002) SHORT INTEGUMENTS1/SUSPENSOR1/CARPEL FACTORY, a Dicer homolog, is a maternal effect gene required for embryo development in Arabidopsis. Plant Physiology 130:808-820.
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Köhler C, Grossniklaus U. (2002) Epigenetics: the flowers that come in from the cold. Curr Biol. 12:129-131.
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Page DR, Grossniklaus U. (2002) The art and design of genetic screens: Arabidopsis thaliana. Nat Rev Genet. 3:124-136.
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Ballesteros L, Bolle C, Lois LM, Moore JM, Vielle-Calzada J-P, Grossniklaus U, Chua N-H. (2001) LAF1, a MYB transcription activator for phytochrome A signaling. Genes Dev. 15:2613-2625.
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Grimanelli D, Leblanc O, Perotti E, Grossniklaus U. (2001) Developmental genetics of gametophytic apomixis. Trends. Genet. 17:597-604.
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Grossniklaus U, Spillane C, Page DR, Köhler C. (2001) Genomic imprinting and seed development: endosperm formation with and without sex. Curr. Opin. Plant Sci. 4:21-27.
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Grossniklaus U. (2001) From sexuality to apomixis: molecular and genetic approaches. In Advances in Apomixis Research (Savidan Y, Carman J, Dresselhaus T. eds). CYMMIT Press, Mexico. pp. 168-211.

Lemieux B, Grossniklaus U. (2001) Paper Alerts in Genomics and Molecular Genetics. Curr. Opin. Plant Biol. 4.

Spillane C, Vielle-Calzada J-P, Grossniklaus U. (2001) APO 2001. A sexy apomixer in Como. Plant Cell 13:1480-1491.
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Budziszewski GJ, Lewis SP, Glover LW, Reineke J, Jones G, Ziemnik LS, Lonowski J, Nyfeler B, Aux G, Zhou Q, McElver J, Patton DA, Martienssen R, Grossniklaus U, Ma H, Law M, Levin JZ. (2001) Arabidopsis Genes Essential for Seedling Viability: Isolation of insertional mutants and molecular cloning. Genetics 159:1765-1778.
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Grossniklaus U, Nogler GA, van Dijk P (2001) How to avoid Sex. The genetic control of gametophytic apomyxis. Plant Cell 13:1491-1998.
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Grossniklaus U. (2001) Apomixis – Nachkommen ohne männliche Beteiligung. Briefe aus dem Bot. Garten 35 (6).

Hecht V, Vielle-Calzada J-P, Hartog MV, Schmidt EDL, Boutilier K, Grossniklaus U, de Vries SC. (2001) The Arabidopsis SOMATIC EMBRYOGENESIS RECEPTOR KINASE 1 Gene Is Expressed in Developing Ovules and Embryos and Enhances Embryogenic Competence in Culture. Plant Physiology 127:803-816.
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Spillane C, Steimer A, Grossniklaus U. (2001) Apomixis in agriculture: the quest for clonal seeds. Sex Plant Reprod 14:179-187.
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Vielle-Calzada J-P, Baskar R, Grossniklaus U. (2001) Seed development: Early paternal gene activity in Arabidopsis. Nature 414:6865.

Grossniklaus U. (2000) Sex, Plants and Rock’n Roll: Die genetischen Grundlagen der Fortpflanzungsbiologie bei Pflanzen. Forschung für Leben 58:18-23.

Pruitt RE, Vielle-Calzada J-P, Ploense SE, Grossniklaus U, Lolle SJ. (2000) FIDDLEHEAD, a gene required to suppress epidermal cell interactions in Arabidopsis, encodes a putative lipid biosynthetic enzyme. Proc Natl Acad Sci USA. 97:1311-1316.
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Spillane C, MacDougall C, Stock C, Köhler C, Vielle-Calzada J-P, Nunes SM, Grossniklaus U, Goodrich J. (2000) Interaction of the Arabidopsis Polycomb group proteins FIE and MEA mediates their common phenotypes. Curr. Biology 10:1535-1538.
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Lemieux B, Grossniklaus U. (2000) Paper Alerts in Genomics and Molecular Genetics. Curr. Opin. Plant Biol. 3.

Siddiqi I, Ganesh G, Grossniklaus U, Subbiah V. (2000) The dyad gene is required for progression through female meiosis in Arabidopsis. Development. 127:197-207.
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Vielle-Calzada J-P, Baskar R, Grossniklaus U. (2000) Delayed activation of the paternal genome during seed development. Nature 404:91-94.
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Lemieux B, Grossniklaus U. (1999) Paper Alerts in Genomics and Molecular Genetics. Curr. Opin. Plant Biol. 2.

Vielle-Calzada J-P, Thomas J, Spillane C, Coluccio A, Hoeppner MA, Grossniklaus U. (1999) Maintenance of genomic imprinting at the Arabidopsis medea locs requires zygotic DDM1 activity. Genes & Dev. 13:2971-2982.
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Messing, J, Grossniklaus U. (1999) Genomic imprinting in plants.In Results and Problems in Cell Differentiation: Genomic Imprinting (Ohlsson R. ed). Springer Verlag, Berlin, Germany, pp. 24-39.

Grossniklaus U, Moore JM, Gagliano WB. (1998) Molecular and genetic approaches to understanding and engineering apomixis: Arabidopsis as a powerful tool. In Advances in Hybrid Rice Technology. Proceedings of the 3^rd International Symposium on Hybrid Rice 1996 (Virmani SS, Siddiq EA, Muralidharan K. eds). International Rice Research Institute, Manila, Philippines, pp. 187-211.

Grossniklaus U, Schneitz K. (1998) Genetic and molecular control of ovule development and megagametogenesis. Seminars in Cell & Devl. Biol. 9:227-238.
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Grossniklaus U, Vielle-Calzada J-P. (1998) Parental conflict and infanticide during embryogenesis. Trends in Plant Sciences. 3:328.

Grossniklaus U, Vielle-Calzada, J-P, Hoeppner MA, Gagliano WB. (1998) Maternal control of embryogenesis by MEDEA, a Polycomb-group gene in Arabidopsis. Science. 280:446-450.
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Howden R, Park S-K, Moore JM, Orme J, Grossniklaus U, Twell D. (1998) Selection of T-DNA-tagged male and female gametophytic mutants by segregation distortion in Arabidopsis. Genetics.149:621-631.
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Vielle-Calzada J-P, Moore JM, Gagliano WB, Grossniklaus U. (1998) Altering sexual development in Arabidopsis. J. Plant Biol. 41:71-83.

Hawkins NC, van Burskik C, Grossniklaus U, Schüpbach T. (1997) Post-transcriptional regulation of gurken by encore is required for axis determination in Drosophila. Development: 124:4801-4810.
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Moore JM, Vielle-Calzada J-P, Gagliano W, Grossniklaus U. (1997) Genetic characterization of hadad, a mutant disrupting megagametogenesis in Arabidopsis thaliana. Cold Spring Harbor Symp. Quant. Biol. 62:35-47.
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Grossniklaus U, Madhusudhan MS, Nanjundiah V. (1996) Non-linear enzyme kinetics can lead to high metabolic flux control coefficients: implications for the evolution of dominance. J. Theor. Biol. 182:299-302.
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Andjelkovic M, Jones PF, Grossniklaus U, Cron P, Schier AF, Dick M, Bilbe G, Hemmings BA. (1995) Developmental regulation of expression and activity of multiple forms of theDrosophila RAC protein kinase. J. Biol. Chem. 270:4066-4075.
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Cadigan KM, Grossniklaus U, Gehring WJ. (1994) Localized expression of sloppy paired protein maintains the polarity of Drosophila parasegments. Genes & Dev. 8:899-913.
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Cadigan KM, Grossniklaus U, Gehrin WJ. (1994) Functional redundancy: The respective roles of the sloppy paired proteins in segmentation. Proc. Natl. Acad. Sci. USA: 91:6324-6328.
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Grossniklaus U, Cadigan KM, Gehring WJ. (1994) Three maternal coordinate systems cooperate in the patterning of the Drosophila head. Development 120:3155-3171.
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Grossniklaus U. (1993) Identification of developmentally regulated genes by enhancer detection: Isolation and characterization of the Drosophila segmentation locus sloppy paired. Ph. D. Thesis, University of Basel, Switzerland.

Grossniklaus U, Pearson RK, Gehring WJ. (1992) The Drosophila sloppy paired locus encodes two proteins involved in segmentation that show homology to mammalian transcription factors. Genes & Dev. 6:1030-1051.
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Häcker U, Grossniklaus U, Gehring WJ, Jäckle H. (1992) Developmentally regulated Drosophila gene family encoding the fork head domain. Proc. Natl. Acad. Sci. USA 89:8754-8758.
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Bellen HJ, Wilson C, Gibson G, Grossniklaus U, Pearson RK, O'Kane CJ, Gehring WJ. (1990) P-element-mediated enhancer detection allows rapid identification of developmentally regulated genes and cell-specific markers in Drosophila. J. Physiol. Paris 84:1-10.
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